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A major limitation to the analysis was a high degree of methodological differences between the clinical trials

As NAD+ drops, cells become senescent and trigger inflammation

It is primarily studied in cell culture and animal models and is not an approved human therapeutic

Last reviewed: May 29, 2026 Last updated: May 29, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

However, these effects were observed only in the intention-to-treat analysis, not the per-protocol population