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Given that metformin is likely to have only a small impact on DPP4 activity, it is likely that the main impact of metformin on GLP-1 is to increase GLP-1 secretion
2004 Aug;137(2):225-33 34e Molitch ME, Gillam MP
Without adequate inflammation, healing impaired (immunosuppressed patients show delayed fracture healing)
Because of this, patients should avoid starting treatment with unrealistic expectations if they are unable to continue treatment safely or sustainably
Suspected adverse reactions to retatrutide within a trial should be reported to the trial team and can also be submitted to the MHRA via the Yellow Card scheme
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