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Geometric mean (% coefficient of variation) baseline hsCRP values were 2.8 (153) mg/L in SUSTAIN 3, 2.9 (173) mg/L in PIONEER 1, 2.7 (171) mg/L in PIONEER 2, and 3.0 (141) mg/L in PIONEER 5

Although we need human studies to conclude with any certainty, taking certain probiotic strains could theoretically help improve histamine intolerance 13

Important safety considerations include the risk of pancreatitis (all GLP-1 agonists carry warnings about this), gallbladder disease (more common with greater weight loss), and a caution with semaglutide in patients with pre-existing diabetic retinopathy, where rapid improvement in glucose control may temporarily worsen retinopathy

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